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Epidemiologia e Serviços de Saúde
versión impresa ISSN 1679-4974versión On-line ISSN 2237-9622
Resumen
ALMEIDA, Ariely Nunes Ferreira de et al. Surveillance of cutaneous leishmaniasis in clinical samples: distribution of Leishmania guyanensis in the state of Amapá, Brazil, 2018. Epidemiol. Serv. Saúde [online]. 2020, vol.29, n.1, e2018504. Epub 05-Feb-2020. ISSN 1679-4974. http://dx.doi.org/10.5123/s1679-49742020000100007.
Objective:
to investigate Leishmania species in a series of autochthonous cutaneous leishmaniasis (CL) cases in Amapá State, Brazilian Amazon.
Methods:
this was a descriptive ecological study carried out from January-October/2018 at a reference center for CL diagnosis in Amapá; individuals with CL receiving care from January-May/2018 were recruited; clinical data and skin biopsies were obtained; from extracted DNA (phenol-chloroform) we amplified the hsp70-234 gene region (PCR) for nucleotide sequencing (Applied Biosystems: ABI3500XL).
Results:
38 individuals were interviewed, examined and diagnosed; men predominated (28/38; mean age=32.5±11.3); lesions (most ulcers: 37/38) measuring 0,4-10mm (34/38) and ≥11mm (4/38) were multiple in 20/38 individuals; diagnosis of L. braziliensis (1), L. naiffi (1), L. infantum (1), L. (Viannia) sp. (1), L. amazonensis (2) and L. guyanensis (32); individuals infected with L. guyanensis (32/38) lived in 9/10 municipalities represented in the sample, and 17/32 of these had multiple lesions.
Conclusion:
presence of Leishmania guyanensis predominated and was frequently associated with multiple lesions.
Palabras clave : Leishmaniasis, Cutaneous; Leishmania guyanensis; Molecular Epidemiology; Amazonian Ecosystem; Epidemiology, Descriptive.