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Revista Pan-Amazônica de Saúde

versão impressa ISSN 2176-6215versão On-line ISSN 2176-6223

Resumo

LIMA, Dayane Pereira de; MENDES, Gabriella da Silva  e  SANTOS, Norma. Isolation, typing, and acyclovir susceptibility of human herpesvirus 1 and 2 detected in Rio de Janeiro, Brazil. Rev Pan-Amaz Saude [online]. 2023, vol.14, e202301253.  Epub 15-Mar-2023. ISSN 2176-6215.  http://dx.doi.org/10.5123/s2176-6223202301253.

OBJECTIVES:

To isolate and identify human herpesvirus (HHV) strains circulating in healthy individuals in Rio de Janeiro, Brazil, and characterize their acyclovir (ACV) susceptibility.

MATERIALS AND METHODS:

Fifteen swabs from cutaneous or mucosal lesions were used to inoculate Vero cells for viral propagation. The species of the isolates were identified by amplifying and sequencing a portion of the conserved region of the herpesvirus DNA polymerase gene. ACV susceptibility was determined using dose-response assays.

RESULTS:

HHV strains were isolated from all 15 samples. Ten isolates belonged to species HHV-1 and five to species HHV-2. Susceptibility assays showed that 13 isolates were sensitive to ACV, one had intermediate resistance, and one was resistant.

CONCLUSION:

The results presented in this study demonstrate the circulation of HHV-1 and HHV-2 in healthy individuals in Rio de Janeiro, including ACV-resistant strains, and highlight the need for continued surveillance in the face of the emergence of HHV strains resistant to antiviral drugs used in the treatment of these infections.

Palavras-chave : Human Herpesvirus 1; Human Herpesvirus 2; Acyclovir; Drug Resistance, Viral.

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