Abstract

PACHECO, Antônio Carlos Chalu; LIMA, Isamu Komatsu  and  CONCEICAO JUNIOR, Vítor Moutinho da. Relation of serum levels of CEA whit the attack regional lymph in preoperative patients with gastric cancer. Rev. Para. Med. [online]. 2006, vol.20, n.4, pp.29-33. ISSN 0101-5907.

Objective: study a possible relation between serum levels of CEA and the lymph-node acess of the patient who have gastric adenocarcinoma. Method: transversalis analysis of 30 (thirty) patients carriers of gastric adenocarcinoma whose clinical and surgical stages have not showed disseminated or non-ressectable disease. With this data, blood samples were collected in order to perform the tumor markers dosage previously mentioned. Then, they were submitted to laparotomy with intraoperatory staging. Whether there were no sings of irressecability or metastases, a pretentiously curative gastrectomy, which could be total or subtotal, with major and minor omentectomy and D2 lyphadenectomy was performed. All lymph-nodes ressected from patients were submitted to hystopathological exam with hematoxilin-eosin preparation. Results and conclusions: CEA levels were above normal in six patients (20%). However, there were metastases in on or more lymph-nodes resected from seventeen patients (56,66%). In order to perform a statistical study of a possible relation between these markers serum levels and lymph-node metastases, Binominal, Kolmogorov-Smirnov and Fisher tests were used, according to the studied variables. Finally, there was no significant correlation between pre-operatory serum levels of the studied markers and regional lymphnodal metastases in gastric cancer patients submitted to gastric ressection with curative intention (p>0,05).

Keywords : carcino-embrionic antigen; radical gastrectomy; tumor markers; gastric cancer.

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