Resumo

CUNHA, Sergio et al. Associação entre meningite asséptica e uso da vacina tríplice viral (sarampo-caxumba-rubéola) durante campanha vacinal de 1997. Inf. Epidemiol. Sus [online]. 1998, vol.7, n.1, pp.29-61. ISSN 0104-1673.  http://dx.doi.org/10.5123/S0104-16731998000100003.

In 1997 a mass vaccination campaign with the measles, mumps and rubella vaccine was carried out in four Brazilian states: Rio Grande do Sul, Bahia, Piauí and Ceará. Three weeks after the special vaccination day, an increase was observed in the number of cases of aseptic meningitis in the capitals of the four states. An investigation was undertaken by health professionals from the State Health Secretaries, professionals from the Institute of Collective Health and the Medical School of the Federal University of Bahia with the support of the National Immunization Program. The results of the investigation demonstrated the occurrence of an outbreak of aseptic meningitis which initiated abruptly two to three weeks after the special vaccination day, with a total duration of four week. It was also shown that the risk of aseptic meningitis was greater 21-30 days after exposure to the vaccine when compared to the risk before the campaign. Only in Salvador the outbreak caused an excess of cases that extrapolated the admission capability of the reference hospital for infectious diseases. This work discusses the determinants of the outbreak, the implications for adequate medical assistance and the implications regarding societal credibility of the safety of the vaccines used in the routine vaccination calendar.

Palavras-chave : Vaccine Adverse Events; MMR Vaccine; Aseptic Meningitis.

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