Abstract

WILLEMANN, Maria Cristina Antunes; GOES, Fernanda Caroline Silva; ARAUJO, Ana Catarina Melo  and  DOMINGUES, Carla Magda Alan Santos. Pertussis and number of doses of vaccine administered: a case control study. Epidemiol. Serv. Saúde [online]. 2014, vol.23, n.2, pp.207-214. ISSN 1679-4974.

OBJECTIVE: estimate the likelihood of pertussis according to number of vaccine doses received and age. METHODS: Case-control study using 2007-2011 SINAN data. "Cases" were considered to be confirmed reported pertussis cases. "Controls" were the discarded cases. RESULTS: 5,389 cases and 10,689 controls were included. In those aged 7-12 months, cases were twice as likely [OR:2.1 (95%CI:1.3-3.4)] when only 1 instead of 3 doses had been administered. In 1-3 year-olds, likelihood was greater in those not having boosters (1 booster expected) [OR 1 dose: 2.4 (95%CI:1.6-3.8); OR 2 doses: 3.6 (95%CI:2.2-6.1); OR 3 doses: 1.6 (95%CI:1.3-2.2); OR 0 dose: 2.8 (95%CI:1.7-4.8)]. In 7-15 year-olds, cases were 60% more likely in those having had 1 booster instead of 2 [OR:1.6 (95%CI:1.2-2.3)]. CONCLUSION: incomplete immunization increases likelihood of contracting pertussis in all age groups studied, mainly 7-15 years.

Keywords : Pertussis Vaccine; Whooping Cough; Immunization Schedule; Disease Notification; Case-Control Studies.

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