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Epidemiologia e Serviços de Saúde

versión impresa ISSN 1679-4974versión On-line ISSN 2237-9622


SAMPAIO, Gilmara de Souza et al. Expansion of Zika virus circulation from Africa to the Americas, 1947-2018: a literature review. Epidemiol. Serv. Saúde [online]. 2019, vol.28, n.2, e2018411.  Epub 22-Ago-2019. ISSN 1679-4974.


to describe the temporal and geographical expansion of Zika virus (ZIKV) circulation in countries and territories, from the time it was first isolated until 2018.


This was a non-systematic literature review covering the period from 1947 to 2018 using the MEDLINE database and World Health Organization estimates.


Since its isolation in 1947, ZIKV circulation spread through Africa, Asia and the Pacific before reaching the Americas in 2013, causing serious clinical manifestations; the highest seroprevalence rates were recorded in Yap (74%) and in Brazil (63%); genetic mutations, absence of immunity and high vector susceptibility may have influenced ZIKV transmissibility and help to explain the magnitude of its expansion.


The spread of ZIKV circulation in the Americas was the most extensive recorded thus far, possibly as a result of population and geographical characteristics of the sites where the virus circulated.

Palabras clave : Zika Virus, Flavivirus; Epidemiology; Epidemics; Congenital Abnormalities; Review Literature as Topic.

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