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Epidemiologia e Serviços de Saúde

versão impressa ISSN 1679-4974versão On-line ISSN 2237-9622

Resumo

LUCENA, Adriana Regina Farias Pontes et al. Factors associated with severity of adverse events following yellow fever vaccination during the biggest outbreak of the disease recorded in Brazil, 2016-2017. Epidemiol. Serv. Saúde [online]. 2020, vol.29, n.1, e2018331.  Epub 09-Mar-2020. ISSN 1679-4974.  http://dx.doi.org/10.5123/s1679-49742020000100017.

Objective:

to analyze characteristics, incidence and factors associated with serious adverse events (SAEs) following yellow fever vaccination during an outbreak of the disease in Brazil (2016-2017).

Methods:

this was a case-control study using data from the National Immunization Program Information System (SI-PNI); SAE were considered to be cases, and non-serious adverse events (NSAE) were considered to be controls.

Results:

we analyzed 135 SAE cases and 1,058 controls; of the 135 SAE, 79 (58.5%) were males and median age was 28 years [09-49]; incidence in January 2017 reached 1.3 case per 100,000 vaccine doses administered; there was statistical association with males (Odds Ratio [OR]=1.73 - 95%CI 1.20;2.48), primary vaccination (OR=1.65 - 95%CI 1.01;2.71), and being 60 years of age or older taking as reference those aged under 5 (OR=4.4; p-value <0.02).

Conclusion:

SAE owing to yellow fever vaccine showed a greater chance of occurring in men, the elderly and primary vaccination.

Palavras-chave : Vaccines; Yellow Fever; Drug-Related Side Effects and Adverse Reactions; Immunization; Case-Control Studies.

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