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Epidemiologia e Serviços de Saúde

Print version ISSN 1679-4974On-line version ISSN 2237-9622


FULONE, Izabela; SILVA, Marcus Tolentino  and  LOPES, Luciane Cruz. Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017. Epidemiol. Serv. Saúde [online]. 2023, vol.32, n.1, e2022556.  Epub Mar 13, 2023. ISSN 1679-4974.


to investigate sociodemographic and clinical characteristics of users of atypical antipsychotics receiving care via the Specialized Component of Pharmaceutical Assistance (Componente Especializado da Assistência Farmacêutica - CEAF), for the treatment of schizophrenia in Brazil, between 2008 and 2017.


this was a retrospective cohort study using records of the authorizations for high complexity procedures retrieved from the Outpatient Information System of the Brazilian National Health System, from all Brazilian states.


of the 759,654 users, 50.5% were female, from the Southeast region (60.2%), diagnosed with paranoid schizophrenia (77.6%); it could be seen a higher prevalence of the use of risperidone (63.3%) among children/adolescents; olanzapine (34.0%) in adults; and quetiapine (47.4%) in older adults; about 40% of children/adolescents were in off-label use of antipsychotics according to age; adherence to CEAF was high (82%), and abandonment within six months was 24%.


the findings expand knowledge about the sociodemographic and clinical profile of users and highlight the practice of off-label use.

Keywords : Antipsychotics; Brazilian National Health System; Schizophrenia; Brazil; Off-Label Use; Cohort Studies.

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