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Revista Pan-Amazônica de Saúde

On-line version ISSN 2176-6223

Abstract

CRUZ, Ana Cecília Ribeiro et al. Molecular epidemiology of dengue virus serotypes 2 and 3 isolated in Brazil from 1991 to 2008. Rev Pan-Amaz Saude [online]. 2010, vol.1, n.3, pp.25-34. ISSN 2176-6223.  http://dx.doi.org/10.5123/S2176-62232010000300004.

The dengue virus (DENV1-4) causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) in tropical and subtropical areas. The aim of this study was to evaluate the circulating genotypes of DENV. This was accomplished by sequencing the PrM and E genes of Brazilian isolates of DENV2 and DENV3 that were obtained between 1991 and 2008 from various geographic regions. Phylogenetic analyses of DENV2 demonstrated that the genotype III (Southeast Asian/American), in spite of several nucleotide and amino acid changes, was the only one that circulated over the past 19 years. Since its introduction in 2000, the DENV3 isolates that have been analyzed have all grouped into genotype III (Indian subcontinent) and there has been no evidence of DENV3 belonging to other genotypes in this study.

Keywords : Dengue Virus; Dengue Hemorrhagic Fever; Flavivirus.

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