Abstract

BARBOSA, Eric Lima  and  LEVINO, Antônio. Analysis of TB/HIV coinfection as development factor for multidrug resistant tuberculosis: a systematic review. Rev Pan-Amaz Saude [online]. 2013, vol.4, n.4, pp.57-66. ISSN 2176-6215.  http://dx.doi.org/10.5123/S2176-62232013000400007.

Tuberculosis (TB) is a public health problem, and it has worsened over the past three decades as a result of new cases associated with spreading of human immunodeficiency virus (HIV) epidemic, as well as the growing problem of multidrug resistance used to treat that disease. Through a systematic review of scientific literature, this paper searches if TB/HIV coinfection is related to multidrug resistant tuberculosis (MDR-TB) comparing patients with and without coinfection. The research question was elaborated using PICO strategy where patients are those with TB, intervention is HIV status, comparison is between patients with and without HIV, and outcomes are the diagnosed MDR-TB cases. It was use a total of 808 scientific studies cataloged in MEDLINE/PubMed, LILACS, ISI/Thomson Reuters and SciELO. org databases, which used specific descriptors for each of them. All the submitted papers were selected through the title, abstract, and reading the full text. Only 16 of total met the inclusion criteria, where they are identified as masculine, medium age 39, before treatment history for TB, and low rates of CD4 cells as factors associated to MDR-TB development in coinfected patients. The systematic reviewing concluded that TB/HIV coinfected patients are more likely to develop MDR-TB.

Keywords : Tuberculosis; Coinfection; HIV; Tuberculosis, Multidrug-Resistant.

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