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Revista Pan-Amazônica de Saúde

On-line version ISSN 2176-6223


SILVA, Hudson Lacerda da; OLIVEIRA, Naira Villas Boas de  and  SOLER, Orenzio. Analysis of meta-analyses and clinical trials concerning the use of statins in cardiovascular diseases. Rev Pan-Amaz Saude [online]. 2016, vol.7, n.4, pp.107-119. ISSN 2176-6223.


To seek evidences for the use of statins in cardiovascular diseases and their economic costs in the context Unified Health System (Sistema Único de Saúde).


This is an exploratory, a bibliographic and qualitative research performed by data collection method from the systematic review.


It was observed that the treatment with statins have been considered cost-effective in preventing cardiovascular diseases for high-risk users, when there is reduction of outcomes at low cost, especially in secondary prevention.


It is necessary to review the clinical guidelines about the application of the cost-effectiveness concept and the funding of basic and specialized component of statins (high cost) for the use of simvastatin and atorvastatin and their relationship with the primary and secondary prevention of cardiovascular diseases.

Keywords : HMG-CoA Reductase Inhibitors; Cardiovascular Diseases; Pharmaceutical.

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