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Revista Pan-Amazônica de Saúde

Print version ISSN 2176-6223On-line version ISSN 2176-6223


NUNES, Heloisa Marceliano et al. Occult hepatitis B virus infection in an Amazonian community submitted to intense migratory flow, Pará State, Brazil. Rev Pan-Amaz Saude [online]. 2017, vol.8, n.3, pp.35-49. ISSN 2176-6223.


Occult hepatitis B virus (HBV) infection (OBI) is defined as the presence of HBV DNA in liver, which may or not be detected in the serum with HBsAg-, and its possible clinical implications.


To investigate the OBI occurrence in the population of the municipality of Juruti, Pará State, Brazil, from February 2007 to November 2010.


Serum samples of 3,991 individuals were evaluated by immunoenzymatic techniques. The ones anti-HBc total+ isolated were selected, and from these the HBV DNA was investigated to identify OBI presence.


In relation to HBV, the study showed 0.5% of carriers, 8.3% with a previous infection profile, 1.1% with a previous or current infection profile, and 33.6% with a vaccine response, characterizing that municipality as low endemicity for this virus. HBV DNA was detected in 66.7% of the HBsAg+ samples, with viral load between < 55 IU/mL and > 38,000 IU/mL; 69.2% of these samples were A1 subgenotype, 15.4% F2, and 15.4% F4. Of the total, 1.1% were samples from individuals anti-HBc total+ isolated whose molecular biology tests showed that 9.3% had HBV DNA, with viral load between < 15 IU/mL and 48 IU/mL.


The findings of this study indicated the presence of OBI carriers in 0.1% of the Juruti population. The low prevalence of OBI found is probably related to the low endemicity of HBV in this population.

Keywords : Hepatitis B virus; Human Viral Hepatitis; Genotyping Techniques.

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