SciELO - Scientific Electronic Library Online

vol.11Avaliação da atividade antibacteriana de plantas medicinais de uso popular: Alternanthera brasiliana (penicilina), Plantago major (tansagem), Arctostaphylos uva-ursi (uva-ursi) e Phyllanthus niruri (quebra-pedra)Acceso a servicios de salud por ribereños de un municipio en el interior del estado de Amazonas, Brasil índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO


Revista Pan-Amazônica de Saúde

versión impresa ISSN 2176-6215versión On-line ISSN 2176-6223


OLIVEIRA, Consuelo Silva de et al. Clinical follow-up of children with in utero Zika virus exposure in the Metropolitan Region of Belém, Pará State, Brazil. Rev Pan-Amaz Saude [online]. 2020, vol.11, e202000216.  Epub 23-Mar-2020. ISSN 2176-6215.


The emergence of the Zika virus (ZIKV), which severely affected Northeastern Brazil, revealed the occurrence of congenital malformations during pregnancy. Currently, changes have been recorded from physical abnormalities, such as microcephaly, arthrogryposis, and brain abnormalities detected by neuroimaging tests, to behavioral changes as irritability and excitability.


From this perspective, a multidisciplinary approach was conducted by clinical follow up and lab and imaging tests, with emphasis on investigating the neurological and psychomotor development, vision and hearing in order to get information on maternal and fetal infection.


For that purpose, 92 children born to women infected by ZIKV during pregnancy were followed up from August 2017 to July 2018.


Among the patients investigated, 55 (59.8%) children were male; 46 (50.0%) mothers were infected in the second trimester of pregnancy; two (2.2%) children had microcephaly at birth and one (1.1%) presented signs and symptoms associated with postnatal microcephaly. In addition, during clinical follow-up, behavioral changes that could affect child neurodevelopment were found, such as extreme irritability, with significant incidence (p < 0.0001), followed by aggressiveness and hyperexcitability, despite normal imaging tests.


According to these results, must be enhanced the need for multi-professional follow up of children with in utero ZIKV exposure in order to identify early and late changes associated with ZIKV and to conduct psychomotor activities that can reduce the sequelae in child neurodevelopment.

Palabras clave : Zika Virus; Pregnancy; Infection; Child Development; Microcephaly.

        · resumen en Español | Portugués     · texto en Español | Portugués | Inglés     · Español ( pdf ) | Inglés ( pdf ) | Portugués ( pdf )