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Revista Pan-Amazônica de Saúde

versão impressa ISSN 2176-6215versão On-line ISSN 2176-6223


FONSECA, Álvaro Luan Santana et al. Use of Sapajus apella in the standardization of an experimental model for Schistosoma mansoni in neotropical primates. Rev Pan-Amaz Saude [online]. 2021, vol.12, n.esp, e202100273.  Epub 07-Jul-2021. ISSN 2176-6215.


To establish and evaluate an experimental model with non-human neotropical primates Sapajus apella to verify more effective diagnostic methods in the detection of schistosomiasis, supporting new studies that help in the cure and control of this disease.


Six adult primates of the Sapajus apella species were used, randomly distributed in two experimental groups of equal number. Of these, three animals were infected intradermally and three transcutaneously, with suspension of cercariae obtained from naturally infected Biomphalaria glabrata snails. To monitor the infection, urine samples were collected via probe or direct puncture, with the anesthetized animal, and stool samples were collected directly from the cages. The urine samples were examined by the rapid urine test (point-of-care cathodic circulating antigen - POC-CCA) and the stool samples by tests of spontaneous stool sedimentation (HPJ) and Kato-Katz.


The use of transcutaneous and intradermal routes resulted in the infection of two of the three animals evaluated (66.6%) in each experimental group. The POC-CCA test was the first to detect positives (21st day), followed by HPJ (35th day), and Kato-Katz (42nd day) tests.


The model analyzed is viable for reproduction in different studies on schistosomiasis mansoni, as the animals responded satisfactorily to the infection in both routes used, making it possible to verify the practicality of the intradermal route when compared to the transcutaneous one.

Palavras-chave : Schistosoma mansoni; Experimental Infection; Animal Model; Primates; Schistosomiasis Mansoni.

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