<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232016000200059</article-id>
<article-id pub-id-type="doi">10.5123/S2176-62232016000200007</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Mycoplasma infection and inflammatory effects on laboratory rats bred for experimental research]]></article-title>
<article-title xml:lang="pt"><![CDATA[Infecção por micoplasma e efeitos inflamatórios em roedores criados em laboratório para pesquisa experimental]]></article-title>
<article-title xml:lang="es"><![CDATA[Infección por micoplasma y efectos inflamatorios en roedores criados en laboratorio para investigación experimental]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ceola]]></surname>
<given-names><![CDATA[Camila Fernandes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sampaio]]></surname>
<given-names><![CDATA[Janaina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blatt]]></surname>
<given-names><![CDATA[Solange Lúcia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cordova]]></surname>
<given-names><![CDATA[Caio Maurício Mendes de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundação Universidade Regional de Blumenau Departamento de Ciências Farmacêuticas ]]></institution>
<addr-line><![CDATA[Blumenau Santa Catarina]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal de Santa Catarina Departamento de Análises Clínicas ]]></institution>
<addr-line><![CDATA[Florianópolis Santa Catarina]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundação Universidade Regional de Blumenau Programa de Pós-Graduação em Química ]]></institution>
<addr-line><![CDATA[Blumenau Santa Catarina]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<volume>7</volume>
<numero>2</numero>
<fpage>59</fpage>
<lpage>66</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232016000200059&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232016000200059&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232016000200059&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Mycoplasma pulmonis is the agent of murine respiratory mycoplasmosis and is the most frequently isolated species from laboratory rats. One of the important consequences of its infection is the reduction of breeding rates and significant interferences in the experiments using these animals. Its experimental infection is also considered a model for studying human infection by M. pneumoniae. We have recently reported M. pulmonis infection rates of up to 75% in rodents bred in facilities for experimental research; however, its effect in the animals' immune system was not evaluated. Therefore, the aim of this work was to investigate the effect of M. pulmonis in rats bred at the animal facility of University of Blumenau, by polymerase chain reaction and culture, in order to verify the viability of the use of these animals for experimentation. Inflammatory parameters, such as C-reactive protein (CRP) and alpha-1 acid glycoprotein (A1GP), as well as haematological parameters were determined from blood samples. It was observed a positivity rate of 80% of M. pulmonis infection. It was also noticed that mycoplasma infection was associated with increased CRP and A1GP levels, as well as blood monocytes. Considering that the possibility of mycoplasma infection is a well-known issue, and that the routine examinations and preventive measures have been well standardised internationally for many years, the findings of this study indicate that the use of the evaluated animals is inacceptable for experimental research. It is strongly advisable that laboratories which conduct this kind of research should be assured of the absence of mycoplasma infection in the animals were used.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO Mycoplasma pulmonis é o agente da micoplasmose respiratória murina, sendo a espécie mais frequentemente isolada em roedores de laboratórios. Uma das importantes consequências de sua infecção é a redução de taxas de reprodução e significantes interferências nos experimentos usando esses animais. Sua infecção experimental é também considerada um modelo para estudos de infecção pelo M. pneumoniae. Atualmente foram relatadas taxas de infecção por M. pulmonis de até 75% em roedores criados em locais de pesquisas experimentais; no entanto, este efeito no sistema imunológico dos animais ainda não foi avaliado. Portanto, o objetivo deste estudo foi o de investigar o efeito do M. pulmonis em roedores criados em instalações da Universidade de Blumenau pela reação em cadeia por polimerase, a fim de verificar a viabilidade do uso desses animais para experiências. Parâmetros de inflamação tais como proteína C reativa (PCR) e alpha-1 glicoproteína ácida (AGPA), assim como os parâmetros hematológicos foram determinados por meio de amostras de sangue. Foi observada taxa de positividade de 80% de infecção por M. pulmonis e, também, que a infecção por micoplasma estava associada ao aumento dos níveis de PCR e AGPA, assim como os monócitos. Considerando que a possibilidade da infecção por micoplasma ser um assunto conhecido e que exames de rotina e medidas preventivas têm sido internacionalmente padronizados por muitos anos, os achados deste estudo indicam que a utilização dos animais avaliados é inaceitável para a pesquisa experimental. É extremamente aconselhável que os laboratórios que conduzem esse tipo de pesquisa estejam seguros quanto à ausência de infecção por micoplasma nos animais que foram usados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Mycoplasma pulmonis es el agente de la micoplasmosis respiratoria murina, siendo la especia más frecuentemente aislada en roedores de laboratorios. Una de las importantes consecuencias de la infección es la reducción de las tasas de reproducción y significativas interferencias en los experimentos usando esos animales. Su infección experimental está también considerada un modelo para estudios de infección por M. pneumoniae. Actualmente han sido relatadas tasas de infección por M. pulmonis de hasta un 75% en roedores criados en locales de investigaciones experimentales; sin embargo, este efecto en el sistema inmunológico de los animales todavía no ha sido evaluado. Por lo tanto, el objetivo de este estudio fue el de investigar el efecto del M. pulmonis en roedores criados en instalaciones de la Universidad de Blumenau por la reacción en cadena de la polimerasa, con el fin de verificar la viabilidad del uso de esos animales para experiencias. Parámetros de inflamación tales como proteína C reactiva (PCR) y alpha-1 glicoproteína ácida (AGPA), así como los parámetros hematológicos se determinaron a través de muestras de sangre. Se observó una tasa de positividad de 80% de infección por M. pulmonis y, también, que la infección por micoplasma estaba asociada al aumento de los niveles de PCR y AGPA, bien como de los monocitos. Considerando que la posibilidad de que la infección por micoplasma es un tema conocido, y que los exámenes de rutina y las medidas preventivas han sido internacionalmente estandarizadas durante años, los hallazgos de este estudio indican que la utilización de los animales evaluados es inaceptable para la investigación experimental. Se aconseja vehementemente que los laboratorios que conducen este tipo de investigación estén seguros con relación a la ausencia de infección por micoplasma en los animales que fueron usados.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Rats]]></kwd>
<kwd lng="en"><![CDATA[Mycoplasmas]]></kwd>
<kwd lng="en"><![CDATA[Lung Diseases]]></kwd>
<kwd lng="en"><![CDATA[Hematology]]></kwd>
<kwd lng="en"><![CDATA[Clinical Chemistry]]></kwd>
<kwd lng="en"><![CDATA[Immunology]]></kwd>
<kwd lng="pt"><![CDATA[Ratos]]></kwd>
<kwd lng="pt"><![CDATA[Micoplasmas]]></kwd>
<kwd lng="pt"><![CDATA[Pneumopatias]]></kwd>
<kwd lng="pt"><![CDATA[Hematologia]]></kwd>
<kwd lng="pt"><![CDATA[Química Clínica]]></kwd>
<kwd lng="pt"><![CDATA[Imunologia]]></kwd>
<kwd lng="es"><![CDATA[Ratas]]></kwd>
<kwd lng="es"><![CDATA[Micoplasmas]]></kwd>
<kwd lng="es"><![CDATA[Enfermedades Pulmonares]]></kwd>
<kwd lng="es"><![CDATA[Hematología]]></kwd>
<kwd lng="es"><![CDATA[Química Clínica]]></kwd>
<kwd lng="es"><![CDATA[Inmunología]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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