<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232017000200013</article-id>
<article-id pub-id-type="doi">10.5123/s2176-62232017000200002</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira]]></article-title>
<article-title xml:lang="en"><![CDATA[Influence of Plasmodium vivax infection on hematological and hepatic markers in patients from a city of the Brazilian Amazon Region]]></article-title>
<article-title xml:lang="es"><![CDATA[Influencia de la infección por Plasmodium vivax en los marcadores hematológicos y hepáticos en pacientes de un municipio de la Región Amazónica brasileña]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[Allyson Guimarães da]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3 "/>
<xref ref-type="aff" rid="Af4"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tarragô]]></surname>
<given-names><![CDATA[Andréa Monteiro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[Nadja Pinto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pimentel]]></surname>
<given-names><![CDATA[João Paulo Diniz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Neves]]></surname>
<given-names><![CDATA[Walter Luiz Lima]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Melo]]></surname>
<given-names><![CDATA[Giane Zupellari dos Santos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Heckmann]]></surname>
<given-names><![CDATA[Maria Izabel Ovellar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Malheiro]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade do Estado do Amazonas  ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundação de Medicina Tropical Dr. Heitor Vieira Dourado  ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas Departamento de Ensino e Pesquisa ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade do Estado do Amazonas  ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidade Federal do Amazonas Instituto de Ciências Biológicas ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>8</volume>
<numero>2</numero>
<fpage>13</fpage>
<lpage>21</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232017000200013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232017000200013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232017000200013&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  OBJETIVO:  Avaliar as principais alterações hematológicas e dos marcadores hepáticos (AST e ALT) em pacientes infectados com Plasmodium vivax atendidos no Instituto de Medicina Tropical de Coari, estado do Amazonas, Brasil.  MATERIAIS E MÉTODOS:  Foram coletadas amostras de 77 pacientes infectados com P. vivax e de 58 indivíduos controle. O hemograma completo e as dosagens de alanina aminotransferase (ALT) e aspartato aminotransferase (AST) foram realizados na Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. As análises estatísticas foram realizadas com o software GraphPad Prism v5.0.  RESULTADOS:  Foi observado que a maior parte dos pacientes, durante a coleta, apresentou como queixas mialgia (92%), fraqueza (87%), dispneia (84%), calafrios (75%) e febre (69%), além de terem tido um aumento nas concentrações das enzimas hepáticas AST e ALT. Em relação às características hematológicas, observaram-se leucopenia, plaquetopenia e diminuição significativa na concentração da hemoglobina globular média e no volume globular médio.  CONCLUSÃO:  Os resultados sugerem que a presença dessas alterações hematológicas e o aumento na carga parasitária não influenciaram o aparecimento de casos graves da doença; porém alterações nas concentrações de AST e ALT podem indicar comprometimento hepático. Além disso, as redes de interações entre os componentes avaliados na infecção por P. vivax podem ser utilizadas como ferramenta de prognóstico em estudos futuros.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  OBJECTIVE:  To evaluate the main hematological changes and hepatic markers (AST and ALT) in patients infected with Plasmodium vivax treated at Instituto de Medicina Tropical de Coari, Amazonas State, Brazil.  MATERIALS AND METHODS:  Samples were collected from 77 patients infected with P. vivax and 58 control subjects. The complete blood count and dosages of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were performed at Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Statistical analyzes were performed with GraphPad Prism v5.0 software.  RESULTS:  It was observed, during collection, that most of the patients complained of myalgia (92%), asthenia (87%), dyspnea (84%), chills (75%), and fever (69%), besides having an increase in the concentrations of the AST and ALT enzymes. About hematological characteristics, leucopenia, thrombocytopenia and a significant decrease in mean globular hemoglobin concentration and mean globular volume were observed.  CONCLUSION:  The results suggest that the presence of these hematological changes and the increase in the parasite load did not influence the occurrence of severe cases of that disease; but changes in the concentrations of AST and ALT may indicate hepatic impairment. In addition, the interaction networks among the components evaluated in P. vivax infection can be used as a prognostic tool in future studies.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  OBJETIVO:  Evaluar las principales alteraciones hematológicas y de los marcadores hepáticos (AST y ALT) en pacientes infectados con Plasmodium vivax atendidos en el Instituto de Medicina Tropical de Coari, estado de Amazonas, Brasil.  MATERIALES Y MÉTODOS:  Se recolectaron muestras de 77 pacientes infectados con P. vivax y de 58 individuos control. El hemograma completo y los dosajes de alanina aminotransferasa (ALT) y aspartato aminotransferasa (AST) se realizaron en la Fundación Hospitalaria de Hematología y Hemoterapia de Amazonas. Los análisis estadísticos se hicieron en el software GraphPad Prism v5.0.  RESULTADOS:  Se observó que la mayor parte de los pacientes, durante la colecta, presentó como quejas mialgia (92%), debilidad (87%), disnea (84%), escalofríos (75%) y fiebre (69%), además de haber tenido un aumento en las concentraciones de las enzimas hepáticas AST y ALT. En relación a las características hematológicas, se observaron leucopenia, plaquetopenia y disminución significativa en la concentración de la hemoglobina globular promedio y en el volumen globular promedio.  CONCLUSIÓN:  Los resultados sugieren que la presencia de esas alteraciones hematológicas y el aumento en la carga parasitaria no influyeron en el aparecimiento de casos graves de la enfermedad; pero, alteraciones en las concentraciones de AST y ALT pueden indicar comprometimiento hepático. Además, las redes de interacciones entre los componentes evaluados en la infección por P. vivax pueden utilizarse como herramienta de pronóstico en estudios futuros.  Palabras clave:  Malaria; Plasmodium vivax; Hematología; Marcadores Hepáticos.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Malária]]></kwd>
<kwd lng="pt"><![CDATA[Plasmodium vivax]]></kwd>
<kwd lng="pt"><![CDATA[Hematologia]]></kwd>
<kwd lng="pt"><![CDATA[Marcadores Hepáticos]]></kwd>
<kwd lng="en"><![CDATA[Malaria]]></kwd>
<kwd lng="en"><![CDATA[Plasmodium vivax]]></kwd>
<kwd lng="en"><![CDATA[Hematology]]></kwd>
<kwd lng="en"><![CDATA[Hepatic Markers]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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<given-names><![CDATA[VRR]]></given-names>
</name>
<name>
<surname><![CDATA[Queiroz]]></surname>
<given-names><![CDATA[ATL]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[BB]]></given-names>
</name>
<name>
<surname><![CDATA[Barral-Netto]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Malar J]]></source>
<year>2013</year>
<volume>12</volume>
<page-range>69</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
