<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232018000400003</article-id>
<article-id pub-id-type="doi">10.5123/s2176-62232018000400003</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Infection profiles of Mayaro virus and Chikungunya virus in mammalian and mosquito cell lineages]]></article-title>
<article-title xml:lang="es"><![CDATA[Perfiles de infección del virus Mayaro y del virus Chikungunya en cepas de células de mamíferos y mosquitos]]></article-title>
<article-title xml:lang="pt"><![CDATA[Perfis de infecção do vírus Mayaro e do vírus Chikungunya em linhagens de células de mamíferos e mosquitos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[Ana Cláudia da Silva]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[Carlos Alberto Marques de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casseb]]></surname>
<given-names><![CDATA[Samir Mansour Moraes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[Sueli Guerreiro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vasconcelos]]></surname>
<given-names><![CDATA[Pedro Fernando da Costa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[Valéria Lima]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Evandro Chagas/SVS/MS Seção de Arbovirologia e Febres Hemorrágicas ]]></institution>
<addr-line><![CDATA[Ananindeua Pará]]></addr-line>
<country>Brasil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>9</volume>
<numero>4</numero>
<fpage>25</fpage>
<lpage>35</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232018000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232018000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232018000400003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  OBJECTIVE: To trace the infection profile of Mayaro virus (MAYV) and Chikungunya virus (CHIKV) in four different cell lineages.  MATERIALS AND METHODS: The isolates of these viruses were used to infect cultures of the following cell lineages - C6/36, VERO, BHK-21, and LLC-MK2 - under the multiplicity of infection of 1 PFU/cell, which were monitored for up to 96 h post-infection (hpi) by phase-contrast microscopy to register the cytopathic effect (CPE); and in addition were subjected to indirect immunofluorescence (iIF) and quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays for virus antigen detection and RNA load determination, respectively.  RESULTS: For both viruses, VERO and BHK-21 cells had CPE of 24 hpi, LLC-MK2 cells presented CPE from 48 hpi, and C6/36 did not present any CPE. In the iIF assays, all cells were already positive at 6 hpi, with the exception of CHIKV-infected LLC-MK2 and BHK-21 cells. Finally, qRT-PCR assays showed that in general cells infected with MAYV presented higher RNA load, although CHIKV-infected LLC-MK2 cells showed the highest RNA load.  CONCLUSION: By evaluating the behavior of these arboviruses in different types of cell cultures, including some not commonly used in the laboratory diagnostic routine, the present study provides not only a better comprehension of the replication kinetics of MAYV and CHIKV, but also opportunities for the optimization of their diagnosis in biological samples.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  OBJETIVO:  Trazar el perfil infeccioso del virus Mayaro (MAYV) y del virus Chikungunya (CHIKV) en cuatro diferentes cepas de células.  MATERIALES Y MÉTODOS:  Los aislados de esos virus se utilizaron para infectar cultivos de las siguientes cepas celulares - C6/36, VERO, BHK-21 y LLC-MK2 - frente a la multiplicidad de infección de 1 PFU/célula, las cuales fueron monitoreadas por hasta 96 h posinfección (hpi) por microscopia de contraste de fase para registrar el efecto citopático (ECP); y enseguida, se sometieron a ensayos de inmunofluorescencia indirecta (IFI) y reacción en cadena de la polimerasa de transcripción inversa cuantitativa (qRT-PCR) para detección de antígenos virales y determinar la carga de ARN, respectivamente.  RESULTADOS:  Para ambos virus, las células VERO y BHK-1 presentaron ECP de 24 hpi, las LLC-MK2 presentaron ECP a partir de 48 hpi y las C6/36 no presentaron ninguna ECP. En los ensayos de IFI, todas las células ya se tornaron positivas a 6 hpi, con excepción de las células LLC-MK2 y BHK-21 infectadas con CHIKV. Finalmente, los ensayos qRT-PCR mostraron que, en general, las células infectadas con MAYV presentaron aumento de la carga de ARN, aunque las células LLC-MK2 infectadas por el CHIKV hayan presentado la mayor carga de ARN.  CONCLUSIÓN:  Al evaluar el comportamiento de esos arbovirus en diferentes tipos de cultivos de células, incluyendo algunos no comúnmente utilizados en la rutina del diagnóstico de laboratorio, el presente estudio ofrece no solo una mejor comprensión de la cinética de replicación de MAYV y CHIKV, sino también oportunidades para la optimización de su diagnóstico en muestras biológicas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  OBJETIVO:  Traçar o perfil infeccioso do vírus Mayaro (MAYV) e do vírus Chikungunya (CHIKV) em quatro diferentes linhagens de células.  MATERIAIS E MÉTODOS:  Os isolados desses vírus foram utilizados para infectar culturas das seguintes linhagens celulares - C6/36, VERO, BHK-21 e LLC-MK2 - sob a multiplicidade de infecção de 1 PFU/célula, as quais foram monitoradas por até 96 h pós-infecção (hpi) por microscopia de contraste de fase para registrar o efeito citopático (CPE); e, em seguida, foram submetidos a ensaios de imunofluorescência indireta (iIF) e reação em cadeia da polimerase de transcrição reversa quantitativa (qRT-PCR) para detecção de antígenos virais e determinação da carga de RNA, respectivamente.  RESULTADOS:  Para ambos os vírus, as células VERO e BHK-21 apresentaram CPE de 24 hpi, as LLC-MK2 apresentaram CPE a partir de 48 hpi e as C6/36 não apresentaram qualquer CPE. Nos ensaios de iIF, todas as células já se tornaram positivas a 6 hpi, com exceção das células LLC-MK2 e BHK-21 infectadas com CHIKV. Finalmente, os ensaios qRT-PCR mostraram que, em geral, as células infectadas com MAYV apresentaram aumento da carga de RNA, embora as células LLC-MK2 infectadas pelo CHIKV tenham apresentado a maior carga de RNA.  CONCLUSÃO:  Ao avaliar o comportamento desses arbovírus em diferentes tipos de culturas de células, incluindo alguns não comumente utilizados na rotina do diagnóstico laboratorial, o presente estudo fornece não apenas uma melhor compreensão da cinética de replicação de MAYV e CHIKV, mas também oportunidades para a otimização de seu diagnóstico em amostras biológicas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Arboviruses]]></kwd>
<kwd lng="en"><![CDATA[Alphavirus]]></kwd>
<kwd lng="en"><![CDATA[Mayaro virus]]></kwd>
<kwd lng="en"><![CDATA[Chikungunya virus]]></kwd>
<kwd lng="en"><![CDATA[Cell Lineage]]></kwd>
<kwd lng="es"><![CDATA[Arbovirus]]></kwd>
<kwd lng="es"><![CDATA[Alphavirus]]></kwd>
<kwd lng="es"><![CDATA[Virus Mayaro]]></kwd>
<kwd lng="es"><![CDATA[Virus Chikungunya]]></kwd>
<kwd lng="es"><![CDATA[Linaje de la Célula]]></kwd>
<kwd lng="pt"><![CDATA[Arbovírus]]></kwd>
<kwd lng="pt"><![CDATA[Alphavirus]]></kwd>
<kwd lng="pt"><![CDATA[Vírus Mayaro]]></kwd>
<kwd lng="pt"><![CDATA[Vírus Chikungunya]]></kwd>
<kwd lng="pt"><![CDATA[Linhagem Celular]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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