<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232020000100018</article-id>
<article-id pub-id-type="doi">10.5123/s2176-6223202000544</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Bioensaio com Allium cepa revela genotoxicidade de herbicida com flumioxazina]]></article-title>
<article-title xml:lang="en"><![CDATA[Allium cepa bioassay reveals genotoxicity of flumioxazin herbicide]]></article-title>
<article-title xml:lang="es"><![CDATA[Bioensayo con Allium cepa revela genotoxicidad de herbicida con flumioxazin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Parvan]]></surname>
<given-names><![CDATA[Lais Gonçalves]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leite]]></surname>
<given-names><![CDATA[Thaís Gonçalves]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[Thaynara Barbosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pedrosa]]></surname>
<given-names><![CDATA[Polyana Aparecida Almeida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calixto]]></surname>
<given-names><![CDATA[Juliana Sena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Agostinho]]></surname>
<given-names><![CDATA[Luciana de Andrade]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A4"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Universitário UNIFAMINAS  ]]></institution>
<addr-line><![CDATA[Muriaé Minas Gerais]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais  ]]></institution>
<addr-line><![CDATA[Muriaé Minas Gerais]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundação Cristiano Varella Hospital do Câncer de Muriaé ]]></institution>
<addr-line><![CDATA[Muriaé Minas Gerais]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Federal do Estado do Rio de Janeiro Programa de Pós-Graduação em Neurologia ]]></institution>
<addr-line><![CDATA[Rio de Janeiro Rio de Janeiro]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>11</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232020000100018&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232020000100018&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232020000100018&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  OBJETIVO: Analisar o potencial genotóxico de um herbicida com flumioxazina pelo bioensaio Allium cepa.  MATERIAIS E MÉTODOS: O herbicida foi testado em duas concentrações: 0,5 g/L (concentração indicada para o uso) e 1,0 g/L (dobro da concentração recomendada). Foram utilizados água destilada como controle negativo e, como controle positivo de citotoxicidade, benzoato de sódio 1%.  RESULTADOS: Os resultados obtidos evidenciaram efeitos de toxicidade em ambas as concentrações do herbicida. Efeitos de citotoxicidade foram observados no herbicida com flumioxazina na concentração de 0,5 g/L, que apresentou padrão microscópico igual ao do controle positivo. Os efeitos de genotoxicidade foram observados em ambas as concentrações (0,5 g/L e 1,0 g/L) que resultaram em aberrações cromossômicas nas células, mostrando que o herbicida interfere diretamente no ciclo celular das células vegetais da cebola.  CONCLUSÃO: O herbicida com flumioxazina apresentou toxicidade e genotoxicidade nas concentrações analisadas e efeitos de citotoxicidade somente na concentração recomendada para o uso.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  OBJECTIVE: To analyze the genotoxic potential of an herbicide with flumioxazin using the Allium cepa bioassay.  MATERIALS AND METHODS: The herbicide was tested in two concentrations: 0.5 g/L (as indicated for use) and 1.0 g/L (twice the recommended concentration). Distilled water was used as a negative control and 1% sodium benzoate as a positive cytotoxicity control.  RESULTS: Toxicity effects were evidenced in both herbicide concentrations. Cytotoxicity effects were observed in the herbicide with flumioxazin at a concentration of 0.5 g/L, which showed a microscopic pattern equal to that of the positive control. The effects of genotoxicity were observed at both concentrations (0.5 g/L and 1.0 g/L) which resulted in chromosomal aberrations in cells, showing that the herbicide directly interferes with the cell cycle of vegetal onion cells.  CONCLUSION: The herbicide with flumioxazin showed toxicity and genotoxicity in the analyzed concentrations and effects of cytotoxicity only in the concentration recommended for use.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  OBJETIVO: Analizar el potencial genotóxico de un herbicida con flumioxazin por el bioensayo Allium cepa.  MATERIALES Y MÉTODOS: El herbicida fue probado en dos concentraciones: 0,5 g/L (concentración indicada para el uso) y 1,0 g/L (doble de la concentración recomendada). Se utilizó agua destilada como control negativo y, como control positivo de citotoxicidad, benzoato de sodio 1%.  RESULTADOS: Los resultados mostraron efectos de toxicidad en ambas concentraciones de herbicidas. Se observaron efectos de citotoxicidad en el herbicida con flumioxazina a una concentración de 0,5 g/L, que presentó un patrón microscópico igual al de control positivo. Los efectos de genotoxicidad se observaron en ambas concentraciones (0,5 g/L y 1,0 g/L) que dieron lugar a aberraciones cromosómicas en las células, mostrando que el herbicida interfiere directamente en el ciclo celular de las células vegetales de la cebolla.  CONCLUSIÓN: El herbicida con flumioxazina presentó toxicidad y genotoxicidad en las concentraciones analizadas y efectos de citotoxicidad solamente en la concentración recomendada para el uso.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Genotoxicidade]]></kwd>
<kwd lng="pt"><![CDATA[Allium cepa]]></kwd>
<kwd lng="pt"><![CDATA[Herbicidas]]></kwd>
<kwd lng="pt"><![CDATA[Índice Mitótico]]></kwd>
<kwd lng="en"><![CDATA[Genotoxicity]]></kwd>
<kwd lng="en"><![CDATA[Allium cepa]]></kwd>
<kwd lng="en"><![CDATA[Herbicides]]></kwd>
<kwd lng="en"><![CDATA[Mitotic Index]]></kwd>
<kwd lng="es"><![CDATA[Genotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[Allium cepa]]></kwd>
<kwd lng="es"><![CDATA[Herbicidas]]></kwd>
<kwd lng="es"><![CDATA[Índice Mitótico]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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