2176-6223 2176-6223 S2176-62232025000100060 10.5123/s2176-6223202501725 Brasil 00 00 2025 00 00 2025 16 1 1977 19 4 4 278-9 2 1982 24 5 5 292-7 3 Ministério da Saúde (BR) 1986 4 1996 74 5 5 491-500 5 2008 371 9619 9619 1181-9 6 2012 107 7 7 846-53