<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1679-4974</journal-id>
<journal-title><![CDATA[Epidemiologia e Serviços de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Epidemiol. Serv. Saúde]]></abbrev-journal-title>
<issn>1679-4974</issn>
<publisher>
<publisher-name><![CDATA[Secretaria de Vigilância em Saúde e Ambiente - Ministério da Saúde do Brasil]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1679-49742023000200303</article-id>
<article-id pub-id-type="doi">10.1590/s2237-96222023000200002</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Trends in mortality from Alzheimer&#8217;s disease in Brazil, 2000-2019]]></article-title>
<article-title xml:lang="es"><![CDATA[Tendencias de mortalidad por enfermedad de Alzheimer en Brasil, 2000 a 2019]]></article-title>
<article-title xml:lang="pt"><![CDATA[Tendência de mortalidade por doença de Alzheimer no Brasil, 2000 a 2019]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paschalidis]]></surname>
<given-names><![CDATA[Mayara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Konstantyner]]></surname>
<given-names><![CDATA[Thais Cláudia Roma de Oliveira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Simon]]></surname>
<given-names><![CDATA[Sharon Sanz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[Camila Bertini]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal de São Paulo Escola Paulista de Medicina ]]></institution>
<addr-line><![CDATA[São Paulo SP]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Columbia University Medical Center  ]]></institution>
<addr-line><![CDATA[New York NY]]></addr-line>
<country>United States</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>32</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S1679-49742023000200303&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S1679-49742023000200303&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S1679-49742023000200303&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective:  to analyze trends in mortality rates due to Alzheimer&#8217;s disease in Brazil and its macro-regions by age and sex, from 2000 to 2019.  Methods: this was a time-series study on mortality from Alzheimer&#8217;s disease in Brazil and its macro-regions by age and sex; data were obtained from the Mortality Information System; a Prais-Winsten model was used to analyze trends.  Results: there were 211,658 deaths in the period analyzed, with an increasing trend in Alzheimer&#8217;s disease mortality in Brazil in elderly people aged 60-69 years (APC = 4.3; 95%CI 2.9;5.9), 70-79 years (APC = 8.1; 95%CI 4.8;11.5) and &#8805; 80 years (APC = 11.3; 95%CI 8.1;14.6) and in all macro-regions, age groups and sexes.  Conclusion:  Brazil and all its macro-regions showed a rising trend in Alzheimer&#8217;s disease mortality rates, following the global trend.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo:  analizar las tendencias en las tasas de mortalidad por enfermedad de Alzheimer en Brasil y sus macrorregiones por grupo de edad y sexo, de 2000 a 2019.  Métodos:  estudio de series temporales de mortalidad por enfermedad de Alzheimer en Brasil y sus macrorregiones por grupo de edad y sexo; los datos se obtuvieron del Sistema de Información sobre Mortalidad del Ministerio de Salud de Brasil; se utilizó el modelo Prais-Winsten para analizar tendencias.  Resultados:  hubo 211.658 óbitos, con tendencia creciente en la mortalidad por enfermedad de Alzheimer en el país, en adultos mayores de 60-69 años (VPA = 4,3; IC95% 2,9;5,9), 70-79 años (VPA = 8,1; IC95%: 4,8;11,5) y &#8805; 80 años (VPA = 11,3; IC95% 8,1;14,6) y en todas las macrorregiones, grupos de edad y sexo.  Conclusión:  Brasil y todas sus macrorregiones mostraron una tendencia creciente en las tasas de mortalidad por enfermedad de Alzheimer siguiendo la tendencia mundial.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Objetivo:  analisar as tendências das taxas de mortalidade por doença de Alzheimer no Brasil e nas suas macrorregiões, por faixa etária e sexo, no período de 2000 a 2019.  Métodos:  estudo de séries temporais sobre mortalidade por doença de Alzheimer no Brasil e suas macrorregiões por faixa etária e sexo; os dados foram extraídos do Sistema de Informação sobre Mortalidade (SIM); o modelo de Prais-Winsten foi utilizado para análise das tendências.  Resultados:  houve 211.658 óbitos no período analisado, com tendência crescente na mortalidade por doença de Alzheimer no país em idosos de 60-69 anos (VPA = 4,3; IC95% 2,9;5,9), 70-79 anos (VPA = 8,1; IC95% 4,8;11,5) e &#8805; 80 anos (VPA = 11,3; IC95% 8,1;14,6), e em todas as macrorregiões, faixas etárias e sexo.  Conclusão:  o Brasil e todas as suas macrorregiões apresentaram tendência crescente nas taxas de mortalidade por doença de Alzheimer, seguindo a tendência mundial.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Alzheimer Disease]]></kwd>
<kwd lng="en"><![CDATA[Mental Health]]></kwd>
<kwd lng="en"><![CDATA[Public Health]]></kwd>
<kwd lng="en"><![CDATA[Time Series Studies]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[Mortality Registries]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad de Alzheimer]]></kwd>
<kwd lng="es"><![CDATA[Salud Mental, Salud Pública]]></kwd>
<kwd lng="es"><![CDATA[Estudios de Series Temporales]]></kwd>
<kwd lng="es"><![CDATA[Mortalidad]]></kwd>
<kwd lng="es"><![CDATA[Registros de Mortalidad]]></kwd>
<kwd lng="pt"><![CDATA[Doença de Alzheimer]]></kwd>
<kwd lng="pt"><![CDATA[Saúde Mental]]></kwd>
<kwd lng="pt"><![CDATA[Saúde Pública]]></kwd>
<kwd lng="pt"><![CDATA[Estudos de Séries Temporais]]></kwd>
<kwd lng="pt"><![CDATA[Mortalidade]]></kwd>
<kwd lng="pt"><![CDATA[Registros de Mortalidade]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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