<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232015000300035</article-id>
<article-id pub-id-type="doi">10.5123/s2176-62232015000300005</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Piassaba palm extractivism as an associated factor with Chagas disease: seroprevalence and immunological profile in native inhabitants of the Central Amazonia, Brazil]]></article-title>
<article-title xml:lang="pt"><![CDATA[O extrativismo da piaçaba como um fator associado à doença de Chagas: soroprevalência e perfil imunológico em habitantes da Amazônia Central, Brasil]]></article-title>
<article-title xml:lang="es"><![CDATA[La extracción de la piasaba como un factor asociado a la enfermedad de Chagas: seroprevalencia y perfil inmunológico en habitantes de la Amazonía Central, Brasil]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duncan]]></surname>
<given-names><![CDATA[Wallice Paxiúba]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Danilow]]></surname>
<given-names><![CDATA[Juliana Leal]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Malheiro]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal do Amazonas Laboratório de Morfologia Funcional Departamento de Morfologia]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal do Amazonas Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal do Amazonas Laboratório de Imunologia Celular Departamento de Parasitologia]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2015</year>
</pub-date>
<volume>6</volume>
<numero>3</numero>
<fpage>35</fpage>
<lpage>42</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232015000300035&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232015000300035&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232015000300035&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT In the Brazilian Amazon, Chagas disease is considered a zoonosis with low virulence and pathogenicity that primarily appears in chronic latent infections. To examine the seroprevalence, epidemiological and immunological profiles of Chagas disease in the microregion of the Negro river (Central Amazonia), an observational and cross-sectional study was conducted on native people from the Municipality of Barcelos, the most important piassaba (Leopoldinia piassaba) fibre extractivism site in the Amazonas State. Serology tests were performed using both ELISA and indirect immunofluorescence tests. Immunophenotyping and profiles of Th1, Th2 and Th17 cytokines were determined. The seroprevalence in native inhabitants ranged from 2.6 to 6.5%. The low level of circulating INF-&#947; was associated to the low percentage of T-helper CD3+ CD4+ lymphocytes. As INF-&#947; is an important factor associated with the development of severe cardiomyopathy, the low levels INF-&#947; in seropositive individuals from the Central Amazonia suggests the downregulation of the Th1 immune response, which might explain the long and latent asymptomatic phase of Trypanosoma cruzi infections.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO Na Amazônia brasileira, a doença de Chagas é considerada uma zoonose com baixa virulência e patogenicidade que aparece principalmente em infecções latentes crônicas. Para examinar a soroprevalência e os perfis epidemiológicos e imunológicos da doença de Chagas na microrregião do Rio Negro (Amazônia Central), um estudo observacional e transversal foi realizado em nativos do Município de Barcelos, local mais importante de extrativismo da piaçaba no Estado do Amazonas. Testes sorológicos foram realizados utilizando tanto os métodos ELISA e de imunofluorescência indireta. Imunofenotipagem e os perfis das citocinas Th1, Th2 e Th17 foram determinados. A soroprevalência em habitantes nativos variou de 2,6 a 6,5%. O baixo nível de circulação de INF-&#947; foi associado à baixa percentagem de linfócitos de T-helper CD4+ CD3+. Como INF-&#947; é um fator importante associado ao desenvolvimento de cardiomiopatia grave, os baixos níveis de IFN-&#947; em indivíduos soropositivos da Amazônia Central sugerem a infrarregulação da resposta imune do tipo Th1, que poderia explicar a longa e latente fase assintomática de infecções de Trypanosoma cruzi.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En la Amazonia brasileña, la enfermedad de Chagas está considerada una zoonosis con baja virulencia y patogenicidad que aparece principalmente en infecciones latentes crónicas. Para examinar la seroprevalencia y los perfiles epidemiológicos e inmunológicos de la enfermedad de Chagas en la microrregión del Rio Negro (Amazonia Central), un estudio de observación y transversal fue realizado en nativos del Municipio de Barcelos, local más importante de extracción de piasaba en el Estado de Amazonas. Se realizaron pruebas serológicas utilizando tanto los métodos ELISA y de inmunofluorescencia indirecta. Se determinó el inmunofenotipo y los perfiles de las citocinas Th1, Th2 y Th17. La seroprevalencia en habitantes nativos varió de 2,6 a 6,5%. El bajo nivel de circulación de INF-&#947; se asoció al bajo porcentaje de linfocitos de T-helper CD4+ CD3+. Como INF-&#947; es un factor importante asociado al desarrollo de cardiomiopatia grave, los bajos niveles de IFN-&#947; en individuos seropositivos de la Amazonia Central sugieren la infrarregulación de la respuesta inmune de tipo Thl, que podría explicar la larga y latente fase asintomática de infecciones de Trypanosoma cruzi.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Chagasic Infection]]></kwd>
<kwd lng="en"><![CDATA[Leopoldinia piassaba]]></kwd>
<kwd lng="en"><![CDATA[Serology]]></kwd>
<kwd lng="en"><![CDATA[Immunophenotyping]]></kwd>
<kwd lng="pt"><![CDATA[Infecção Chagásica]]></kwd>
<kwd lng="pt"><![CDATA[Leopoldinia piassaba]]></kwd>
<kwd lng="pt"><![CDATA[Sorologia]]></kwd>
<kwd lng="pt"><![CDATA[Imunofenotipagem]]></kwd>
<kwd lng="es"><![CDATA[Infección Chagásica]]></kwd>
<kwd lng="es"><![CDATA[Leopoldinia piassaba]]></kwd>
<kwd lng="es"><![CDATA[Serología]]></kwd>
<kwd lng="es"><![CDATA[Inmunofenotipificación]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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