<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232017000100006</article-id>
<article-id pub-id-type="doi">10.5123/s2176-62232017000100006</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Hemoglobinas de origem africana em comunidades quilombolas do estado do Tocantins, Brasil]]></article-title>
<article-title xml:lang="en"><![CDATA[Hemoglobins of African origin in quilombola communities of Tocantins State, Brazil]]></article-title>
<article-title xml:lang="es"><![CDATA[Hemoglobinas de origen africana en comunidades quilombolas del Estado de Tocantins, Brasil]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Teles]]></surname>
<given-names><![CDATA[Annyelle Figueredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Luciana da Costa da]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Amanda Cordeiro da]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[Lidiane Oliveira de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[Márcio Galdino dos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Seibert]]></surname>
<given-names><![CDATA[Carla Simone]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal do Tocantins  ]]></institution>
<addr-line><![CDATA[Porto Nacional Tocantins]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2017</year>
</pub-date>
<volume>8</volume>
<numero>1</numero>
<fpage>39</fpage>
<lpage>46</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232017000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232017000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232017000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  OBJETIVO: Verificar a incidência de hemoglobinas de descendência africana (HbS e HbC) em comunidades quilombolas do estado do Tocantins, Brasil.  MATERIAIS E MÉTODOS: Foi coletado o sangue de quilombolas em 14 comunidades do Estado; a triagem foi realizada em eletroforese de acetato de celulose (pH 8,6), e aquelas com padrão alterado foram submetidas à cromatografia líquida de alta eficiência, sendo registrados o gênero e a idade das pessoas amostradas.  RESULTADOS: A análise dos resultados demonstrou que, dos 822 quilombolas investigados, 95 apresentaram hemoglobinas anormais, sendo 0,5% com doença falciforme (HbSS); 5,7% traço para hemoglobina S (HbAS); 4,9% traço para hemoglobina C (HbAC); 0,2% com hemoglobina fetal aumentada; 0,1% com hemoglobina A2 aumentada; e 88,4% com hemoglobina normal (HbAA). HbSS foi observada na faixa etária infantil e adolescente e HbAS e HbAC em todas as faixas etárias. Em relação ao sexo, não foi possível sugerir o efeito materno para HbS, devido ao maior quantitativo de pessoas do sexo masculino com essa informação genética.  CONCLUSÃO: Neste estudo, a incidência das HbS e HbC, observada nas comunidades quilombolas, esteve dentro do esperado para a Região Norte do Brasil. No entanto, destacam-se a elevada prevalência da doença falciforme e a grande frequência de traço falciforme em algumas das comunidades estudadas, com atenção especial para a região sul do Estado. Desse modo, os resultados aqui apresentados sinalizam risco iminente para o aumento da incidência da doença no Tocantins.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  OBJECTIVE: To verify the incidence of hemoglobins of African descent (HbS and HbC) in quilombola communities in Tocantins State, Brazil.  MATERIALS AND METHODS: Blood samples were collected from 14 quilombola communities in the State; the screening was performed in cellulose acetate electrophoresis (pH 8.6), and those samples with altered standard were submitted to high performance liquid chromatography, recording gender and age of the quilombola people.  RESULTS: The analysis of the results showed that of the 822 quilombolas investigated 95 presented abnormal hemoglobins, 0.5% with sickle cell disease (HbSS); 5.7% for hemoglobin S trait (HbAS); 4.9% for hemoglobin C trait (HbAC); 0.2% with increased fetal hemoglobin; 0.1% with increased hemoglobin A2; and 88.4% with normal hemoglobin (HbAA). HbSS was observed in infant and adolescent groups and HbAS and HbAC in all age groups. About sex, it was not possible to suggest the maternal effect for HbS due to the greater quantitative of males with this genetic information.  CONCLUSION: In the current study the incidence of HbS and HbC observed in quilombola communities was within the expected range for the Northern Region of Brazil. However, the high prevalence of sickle cell disease and the high frequency of sickle cell trait were highlighted in some quilombola communities with special attention to the southern region of the State. Thus, the results presented in this study indicate an imminent risk for the increased incidence of that disease in Tocantins.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  OBJETIVO:  Verificar la incidencia de hemoglobinas de herencia africana en comunidades quilombolas del Estado de Tocantins, Brasil.  MATERIALES Y MÉTODOS:  Se recolectó sangre de quilombolas en 14 comunidades del Estado; la selección se hizo en electroforesis de acetato de celulosa (pH 8,6), y las de patrón alterado fueron sometidas a la cromatografía líquida de alta eficiencia (CLAE), registrándose el género y la edad de las personas del muestreo.  RESULTADOS:  El análisis de los resultados demostró que, de los 822 quilombolas investigados, 95 presentaron hemoglobinas anormales, siendo 0,5% con enfermedad falciforme (HbSS); 5,7% trazo para hemoglobina S (HbAS); 4,9% trazo para hemoglobina C (HbAC); 0,2% con hemoglobina fetal aumentada; 0,1% con hemoglobina A2 aumentada; y 88,4% con hemoglobina normal (HbAA). La enfermedad falciforme se observó en la franja etaria infantil y adolescente y el trazo para HbS y HbC en todas las franjas etarias. En relación al sexo, no fue posible sugerir el efecto materno para HbS debido al mayor número de personas del sexo masculino con esa información genética.  CONCLUSIÓN:  En este estudio, la incidencia de las HbS y HbC, observada en las comunidades quilombolas, estuvo dentro de lo esperado para la Región Norte de Brasil. Sin embargo, se destaca la elevada prevalencia de la enfermedad falciforme y la elevada frecuencia de trazos falciformes en algunas de las comunidades estudiadas, con especial atención para la región sur del Estado. De ese modo, los resultados aquí presentados señalan riesgo inminente para el aumento de la incidencia de la enfermedad en Tocantins.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Anemia Falciforme]]></kwd>
<kwd lng="pt"><![CDATA[Traço Falciforme]]></kwd>
<kwd lng="pt"><![CDATA[Hemoglobina C]]></kwd>
<kwd lng="pt"><![CDATA[Hemoglobina Falciforme]]></kwd>
<kwd lng="en"><![CDATA[Sickle Cell Anemia]]></kwd>
<kwd lng="en"><![CDATA[Sickle Cell Trait]]></kwd>
<kwd lng="en"><![CDATA[Hemoglobin C]]></kwd>
<kwd lng="en"><![CDATA[Sickle Hemoglobin]]></kwd>
<kwd lng="es"><![CDATA[Anemia Falciforme]]></kwd>
<kwd lng="es"><![CDATA[Trazo Falciforme]]></kwd>
<kwd lng="es"><![CDATA[Hemoglobina C]]></kwd>
<kwd lng="es"><![CDATA[Hemoglobina Falciforme]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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