<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232019000100017</article-id>
<article-id pub-id-type="doi">10.5123/s2176-6223201901597</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Chromosomal analyses in genetic counseling of patients with developmental and congenital abnormalities from Belém, Pará State, Brazil: a retrospective study of 17 years]]></article-title>
<article-title xml:lang="pt"><![CDATA[Análises cromossômicas no aconselhamento genético de pacientes com alterações no desenvolvimento e congênitas em Belém, estado do Pará, Brasil: um estudo retrospectivo de 17 anos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[Michel Platini Caldas de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[Savio Monteiro dos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[Margarida Maria Celeira de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[Jacileia Maria Pereira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Melo]]></surname>
<given-names><![CDATA[Marta Maria Maia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[Edivaldo Herculano Corrêa de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerreiro]]></surname>
<given-names><![CDATA[João Farias]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Evandro Chagas Seção de Meio Ambiente Laboratório de Cultura de Tecidos e Citogenética]]></institution>
<addr-line><![CDATA[Ananindeua Pará]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal do Pará Pró-Reitoria de Pesquisa e Pós-Graduação Programa de Bolsas de Iniciação Científica]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal do Pará Instituto de Ciências Biológicas Laboratório de Biologia Molecular Francisco Mauro Salzano]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Federal do Pará Instituto de Ciências Biológicas Laboratório de Citogenética Humana e Clínica]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidade Federal do Pará Instituto de Ciências Exatas e Naturais Faculdade de Ciências Naturais]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>10</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232019000100017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232019000100017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232019000100017&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  OBJECTIVE:  To present a retrospective study covering 17 years of referral of patients to a public clinical cytogenetic service in Belém, Pará State, located in the Brazilian Amazon.  MATERIALS AND METHODS:  This study was based on a retrospective survey conducted from 1997 to 2014, considering registered chromosome G-banding results and relating them to information collected during patient evaluation.  RESULTS:  From a total of 1,580 patients, 730 (46.2%) had chromosomal abnormalities, of which 637 (87.3%) showed numerical alterations. Abnormalities involving autosomal chromosomes were more frequent, 524/730 (71.8%), while alterations in sex chromosomes comprised 28.2% (206). Down's syndrome was the most frequent, 424 (58.1%) of cases, followed by 175 (24.0%) cases of Turner's syndrome, and 25 (3.4%) of Klinefelter's syndrome. Patients with sex chromosome abnormalities were referred at a more advanced age when compared with those having autosomal chromosome abnormalities, with peaks around 11-15 years old (30.1% of cases) and 0-6 months old (40.5%), respectively.  CONCLUSION:  These findings are very similar to other studies and draw attention to public measures to improve both the quality with regard to diagnosis and the subsequent care of the patient.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  OBJETIVO:  Apresentar um estudo retrospectivo, abrangendo 17 anos de encaminhamento de pacientes a um serviço público de citogenética clínica em Belém, estado do Pará, localizado na Amazônia brasileira.  MATERIAIS E MÉTODOS:  Este estudo foi baseado em uma pesquisa retrospectiva realizada de 1997 a 2014, considerando os resultados registrados de bandas G do cromossomo e relacionando-os às informações coletadas durante a avaliação do paciente.  RESULTADOS:  Do total de 1.580 pacientes, 730 (46,2%) apresentaram alterações cromossômicas, dos quais 637 (87,3%) eram alterações numéricas. Anormalidades envolvendo cromossomos autossômicos foram mais frequentes, 524/730 (71,8%), enquanto alterações nos cromossomos sexuais corresponderam a 28,2% (206). A síndrome de Down foi a mais frequente, 424 (58,1%) dos casos, seguida por 175 (24,0%) casos de síndrome de Turner e 25 (3,4%) de síndrome de Klinefelter. Pacientes com anomalias cromossômicas sexuais foram encaminhados com idade mais avançada quando comparados àqueles com anomalias cromossômicas autossômicas, com picos entre 11 e 15 anos (30,1% dos casos) e 0 a 6 meses de idade (40,5%), respectivamente.  CONCLUSÃO:  Esses achados são semelhantes a outros estudos e chamam a atenção para a necessidade de políticas públicas que visem a melhorar tanto a qualidade quanto o diagnóstico e os cuidados subsequentes ao paciente.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Chromosome Disorders]]></kwd>
<kwd lng="en"><![CDATA[Chromosome Banding]]></kwd>
<kwd lng="en"><![CDATA[Congenital Abnormalities]]></kwd>
<kwd lng="en"><![CDATA[Intellectual Disability]]></kwd>
<kwd lng="en"><![CDATA[Cytogenetics]]></kwd>
<kwd lng="pt"><![CDATA[Transtornos Cromossômicos]]></kwd>
<kwd lng="pt"><![CDATA[Bandeamento Cromossômico]]></kwd>
<kwd lng="pt"><![CDATA[Anormalidades Congênitas]]></kwd>
<kwd lng="pt"><![CDATA[Deficiência Intelectual]]></kwd>
<kwd lng="pt"><![CDATA[Citogenética]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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