<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2176-6223</journal-id>
<journal-title><![CDATA[Revista Pan-Amazônica de Saúde]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Pan-Amaz Saude]]></abbrev-journal-title>
<issn>2176-6223</issn>
<publisher>
<publisher-name><![CDATA[Instituto Evandro Chagas. Secretaria de Vigilância em Saúde e Ambiente. Ministério da Saúde]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2176-62232019000100019</article-id>
<article-id pub-id-type="doi">10.5123/s2176-6223201900021</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Presença de clones de hemoglobinúria paroxística noturna em portadores de leucemia aguda do estado do Pará, Amazônia, Brasil]]></article-title>
<article-title xml:lang="en"><![CDATA[Paroxysmal nocturnal hemoglobinuria clones in patients with acute leukemia in Pará State, Brazilian Amazon]]></article-title>
<article-title xml:lang="es"><![CDATA[Presencia de clones de hemoglobinuria paroxística nocturna en portadores de leucemia aguda del estado de Pará, Amazonía, Brasil]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brito Júnior]]></surname>
<given-names><![CDATA[Lacy Cardoso de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[Fábio Rodrigues de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardoso]]></surname>
<given-names><![CDATA[Debora Alves]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Melo]]></surname>
<given-names><![CDATA[Bruno Marcel Silva de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Azevedo]]></surname>
<given-names><![CDATA[Murilo Chermont]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nascimento]]></surname>
<given-names><![CDATA[Matheus Holanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carneiro]]></surname>
<given-names><![CDATA[Debora Monteiro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paixão]]></surname>
<given-names><![CDATA[Ana Paula Silveira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal do Pará Instituto de Ciências Biológicas, Laboratório de Patologia Geral Imunopatologia e Citologia]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal do Pará Instituto de Ciências da Saúde Curso de Especialização em Hematologia e Imunologia]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal do Amapá Departamento de Ciências Biológicas e da Saúde Laboratório de Controle de Qualidade e Bromatologia]]></institution>
<addr-line><![CDATA[Macapá Amapá]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Laboratório de Inflamação e Dor]]></institution>
<addr-line><![CDATA[Ribeirão Preto São Paulo]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidade Federal do Pará Instituto de Ciências da Saúde Faculdade de Medicina]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Laboratório de Patologia Clínica Dr. Paulo C. Azevedo  ]]></institution>
<addr-line><![CDATA[Belém Pará]]></addr-line>
<country>Brasil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>10</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_arttext&amp;pid=S2176-62232019000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_abstract&amp;pid=S2176-62232019000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iec.gov.br/scielo.php?script=sci_pdf&amp;pid=S2176-62232019000100019&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  OBJETIVO:  Evidenciar a melhor estratégia de escolha de anticorpos para caracterizar a presença de clones de hemoglobinúria paroxística noturna (HPN) em pacientes submetidos à investigação diagnóstica de leucemias agudas ou em acompanhamento terapêutico.  MATERIAIS E MÉTODOS:  Foram analisadas 41 amostras de sangue periférico e medula óssea de pacientes portadores de leucemia aguda submetidos à investigação diagnóstica ou em acompanhamento terapêutico de dois hospitais oncológicos e públicos de Belém, de fevereiro a julho de 2015.  RESULTADOS:  Do total de amostras, 58,5% eram do gênero masculino, 41,5% estavam na faixa etária de 0-10 anos, 56,1% estavam em investigação diagnóstica e 43,9% em acompanhamento terapêutico. Dos casos em diagnóstico, 43,5% (10/23) eram de leucemia linfoblástica aguda de células B comum e 26,1% (6/23) de leucemia mieloide aguda. A presença de clones de HPN foi verificada em 9,8% (4/41) do total investigado, sendo 3/4 observados na investigação diagnóstica e 1/4 em paciente em acompanhamento terapêutico, sem recaída. A combinação dos anticorpos FLAER/CD59PE/CD45Per-Cy5 em blastos e linfócitos, FLAER/CD15PE/CD45Per-Cy5/CD24APC em granulócitos e FLAER/CD14PE/CD45Per-Cy5/CD64APC em monócitos mostrou-se como a melhor estratégia para caracterizar a presença de clones de HPN nesses pacientes, independente do tipo de amostra.  CONCLUSÃO:  A presença de clones de HPN em portadores de leucemias agudas não dependeu da ontogenia celular ou do estágio do paciente (diagnóstico ou acompanhamento terapêutico). A melhor estratégia de anticorpos para a identificação de clones HPN em blastos leucêmicos, independente da sua ontogenia, foi por meio da combinação de FLAER com CD45.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  OBJECTIVE:  To highlight the best antibody selection strategy to characterize the presence of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients undergoing diagnostic investigation of acute leukemia or in therapeutic follow-up.  MATERIALS AND METHODS:  Forty-one peripheral blood and bone marrow samples from patients with acute leukemia who underwent diagnostic investigation or therapeutic follow-up at two oncological and public hospitals in Belém, Pará State, Brazil, from February to July 2015, were analyzed.  RESULTS:  A total of 58.5% were male, 41.5% were 0-10 years old, 56.1% were under diagnostic investigation, and 43.9% were under therapeutic follow-up. Among cases under diagnostic investigation, 43.5% (10/23) were B-cell acute lymphoblastic leukemia and 26.1% (6/23) acute myeloid leukemia. The presence of PNH clones was observed in 9.8% (4/41) of cases, being 3/4 under diagnostic investigation and 1/4 under therapeutic follow-up, without relapse. The combination of FLAER/CD59PE/CD45Per-Cy5 antibodies in blasts and lymphocytes, FLAER/CD15PE/CD45Per-Cy5/CD24APC in granulocytes, and FLAER/CD14PE/CD45Per-Cy5/CD64APC in monocytes proved to be the best strategy to characterize the presence of PNH clones in these patients, regardless of sample type.  CONCLUSION:  The presence of PNH clones in patients with acute leukemia did not depend on cell ontogeny or patient stage (diagnosis or therapeutic follow-up). The best antibody strategy for the identification of PNH clones in leukemic blasts, regardless of their ontogeny, was by combining FLAER with CD45.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  OBJETIVO: Descubrir la mejor estrategia para elegir anticuerpos para caracterizar la presencia de clones de hemoglobinuria paroxística nocturna (HPN) en pacientes sometidos a investigación diagnóstica de leucemias agudas o en acompañamiento terapéutico.  MATERIALES Y MÉTODOS: de febrero a julio de 2015, se analizaron 41 muestras de sangre periférica y médula ósea de pacientes con leucemia aguda que se sometieron a una investigación diagnóstica o a acompañamiento terapéutico, en dos hospitales oncológicos y públicos de Belém.  RESULTADOS: del total de muestras, 58.5% eran hombres, 41.5% tenían entre 0 y 10 años, 56.1% estaban en investigación diagnóstica y 43.9% en acompañamiento terapéutico. De los casos en diagnóstico, 43.5% (10/23) era de leucemia linfoblástica aguda de células B común y 26.1% (6/23) de leucemia mieloide aguda. La presencia de clones de HPN se verificó en 9.8% (4/41) del total investigado, con 3/4 observados en la investigación de diagnóstico y 1/4 en un paciente sometido a acompañamiento terapéutico, sin recaída. La combinación de anticuerpos FLAER/CD59PE/CD45Per-Cy5 en blastos y linfocitos, FLAER/CD15PE/CD45Per-Cy5/CD24APC en granulocitos y FLAER/CD14PE/CD45Per-Cy5/CD64APC en monocitos demostró ser la mejor estrategia para caracterizar la presencia de clones de HPN en estos pacientes, independientemente del tipo de muestra.  CONCLUSIÓN: La presencia de clones de HPN en pacientes con leucemia aguda no dependió de la ontogenia celular o la etapa del paciente (diagnóstico o seguimiento terapéutico). La mejor estrategia de anticuerpos para la identificación de clones de HPN en blastos leucémicos, independientemente de su ontogenia, fue a través de la combinación de FLAER con CD45.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Hemoglobinúria Paroxística]]></kwd>
<kwd lng="pt"><![CDATA[Leucemia]]></kwd>
<kwd lng="pt"><![CDATA[Citometria de Fluxo]]></kwd>
<kwd lng="en"><![CDATA[Paroxysmal Hemoglobinuria]]></kwd>
<kwd lng="en"><![CDATA[Leukemia]]></kwd>
<kwd lng="en"><![CDATA[Flow Cytometry]]></kwd>
<kwd lng="es"><![CDATA[Hemoglobinuria Paroxística]]></kwd>
<kwd lng="es"><![CDATA[Leucemia]]></kwd>
<kwd lng="es"><![CDATA[Citometría de Flujo]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brodsky]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Paroxysmal nocturnal hemoglobinuria: stem cells and clonality]]></article-title>
<source><![CDATA[Hematology Am Soc Hematol Educ Program]]></source>
<year>2008</year>
<volume>2008</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>111-5</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Madkaikar]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jijina]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Ghosh]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Paroxysmal nocturnal haemoglobinuria: diagnostic tests, advantages, &amp; limitations]]></article-title>
<source><![CDATA[Eur J Haematol]]></source>
<year>2009</year>
<volume>83</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>503-11</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mortazavi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Merk]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[McIntosh]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Marsh]]></surname>
<given-names><![CDATA[JCW]]></given-names>
</name>
<name>
<surname><![CDATA[Schrezenmeier]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Rutherford]]></surname>
<given-names><![CDATA[TR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): a high incidence of multiple mutations and evidence of a mutational hot spot]]></article-title>
<source><![CDATA[Blood]]></source>
<year>2003</year>
<volume>101</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>2833-41</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brodsky]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Paroxysmal nocturnal hemoglobinuria]]></article-title>
<source><![CDATA[Blood]]></source>
<year>2014</year>
<volume>124</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>2804-11</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Devalet]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Mullier]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Chatelain]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Dogné]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Chatelain]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review]]></article-title>
<source><![CDATA[Eur J Haematol]]></source>
<year>2015</year>
<volume>95</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>190-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Araten]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sanders]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Anscher]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Zamechek]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hunger]]></surname>
<given-names><![CDATA[SP]]></given-names>
</name>
<name>
<surname><![CDATA[Ibrahim]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia]]></article-title>
<source><![CDATA[Am J Pathol]]></source>
<year>2012</year>
<volume>181</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1862-9</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Clemente]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hosono]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Przychodzen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshizato]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria]]></article-title>
<source><![CDATA[J Clin Invest]]></source>
<year>2014</year>
<volume>124</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>4529-38</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schubert]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Roth]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Update on paroxysmal nocturnal haemoglobinuria: on the long way to understand the principles of the disease]]></article-title>
<source><![CDATA[Eur J Haematol]]></source>
<year>2015</year>
<volume>94</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>464-73</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Abdel-Wahab]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance]]></article-title>
<source><![CDATA[J Clin Invest]]></source>
<year>2014</year>
<volume>124</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>4227-30</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Borowitz]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Craig]]></surname>
<given-names><![CDATA[FE]]></given-names>
</name>
<name>
<surname><![CDATA[Digiuseppe]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Illingworth]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Rosse]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Sutherland]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry]]></article-title>
<source><![CDATA[Cytometry B Clin Cytom]]></source>
<year>2010</year>
<volume>78</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>211-30</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lanza]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Lazzari]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Brambilla]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Di Martino]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Spedini]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An unusual association of paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome, and diffuse large B-cell non-Hodgkin lymphoma in a Caucasian man]]></article-title>
<source><![CDATA[Ann Hematol]]></source>
<year>2016</year>
<volume>95</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1555-7</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Araten]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Luzzatto]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)]]></article-title>
<source><![CDATA[Blood]]></source>
<year>2006</year>
<volume>108</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>734-6</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Araten]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bessler]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[McKenzie]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Castro-Malaspina]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Childs]]></surname>
<given-names><![CDATA[BH]]></given-names>
</name>
<name>
<surname><![CDATA[Boulad]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): no evidence for intrinsic growth advantage of PNH clones]]></article-title>
<source><![CDATA[Leukemia]]></source>
<year>2002</year>
<volume>16</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>2243-8</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Inoue]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Izui-Sarumaru]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Murakami]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Endo]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Nishimura]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kurokawa]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)]]></article-title>
<source><![CDATA[Blood]]></source>
<year>2006</year>
<volume>108</volume>
<numero>13</numero>
<issue>13</issue>
<page-range>4232-6</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mortazavi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Tooze]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon-Smith]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
<name>
<surname><![CDATA[Rutherford]]></surname>
<given-names><![CDATA[TR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[N-RAS gene mutation in patients with aplastic anemia and aplastic anemia/ paroxysmal nocturnal hemoglobinuria during evolution to clonal disease]]></article-title>
<source><![CDATA[Blood]]></source>
<year>2000</year>
<volume>95</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>646-50</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katagiri]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Tominaga]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kataoka]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Maeda]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gomyo]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mizuno]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A cure for paroxysmal nocturnal hemoglobinuria using molecular targeted therapy specific to a driver mutation]]></article-title>
<source><![CDATA[Blood]]></source>
<year>2015</year>
<volume>126</volume>
<numero>23</numero>
<issue>23</issue>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Traulsen]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Dingli]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria]]></article-title>
<source><![CDATA[Stem Cells]]></source>
<year>2007</year>
<volume>25</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>3081-4</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dingli]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Traulsen]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multiple mutant clones in blood rarely coexist]]></article-title>
<source><![CDATA[Phys Rev E Stat Nonlin Soft Matter Phys]]></source>
<year>2008</year>
<volume>77</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Clemente]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hosono]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Przychodzen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshizato]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria]]></article-title>
<source><![CDATA[J Clin Invest]]></source>
<year>2014</year>
<volume>124</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>4529-38</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mon Père]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lenaerts]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Dingli]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria]]></article-title>
<source><![CDATA[PLoS Comput Biol]]></source>
<year>2018</year>
<volume>14</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
